Six1: A critical transcription factor in tumorigenesis
نویسندگان
چکیده
منابع مشابه
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1.
Homeobox genes constitute a large family of transcription factors that are essential during normal development and are often dysregulated in cancer. However, the molecular mechanisms by which homeobox genes influence cancer remain largely unknown. Here we show that the tissue-restricted cyclin A1 is a transcriptional target of the Six1 homeoprotein. Both genes are expressed in the embryonic but...
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Homeobox (Hox) genes encode transcription factors that act as critical regulators of growth and differentiation during embryogenesis. While many studies have identified increased expression of Hox genes in tumors, much less is known about the mechanistic basis by which Hox genes facilitate tumor development. In this issue of the JCI, McCoy and colleagues show that transgenic mice that express t...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2014
ISSN: 0020-7136
DOI: 10.1002/ijc.28755